العنوان باللغة الأجنبية:
The Effect of Excipients in Hydrophilic Ointments on The Release Rate of Sodium Diclofenac in Vitro Release System
لمحة عن المقال باللغة الأجنبية:
The release rate of sodium diclofenac has been studied in vitro dialysis system. The substance was suspended in a cellulosic bag into shaked and thermostatic water.
4 hydrophilic ointments were compared to control treatment (non-hydrophilic ointment).The Excipients in different ointments were:
A- Control Treatment contains Vaseline +Vaseline oil
B- Solid Paraffin + Bee Wax + Acetyl Alcohol + Vaseline
C- Hydrous Lanoline +Vaseline
D- Acetyl Alcohol + Vaseline + Lanoline
E- Wax Anionic Emulsifying+ Liquid Paraffin + Vaseline
The drug concentration was 1% in all treatments. The release rates of the drug were: 0.028,0.043,0.048,0.067,0.084mg/ml/2h. For the treatments A, B, C, D & E, successively. Drug releasing was higher in treatment E(0.084mg/ml/2h.), whereas this releasing was lower in treatment A–Control (0.028 mg/ml/2h.).